Target
Apoptosis regulator Bcl-2
Ligand
BDBM354624
Substrate
n/a
Meas. Tech.
Fluorescence Polarisation Assay
IC50
2.20±n/a nM
Citation
 Davidson, JEMurray, JBChen, IWalmsley, CDodsworth, MMeissner, JWBrough, PFejes, ITatai, JNyerges, MKotschy, ASzlávik, ZGeneste, OLe Tiran, ALe Diguarher, THenlin, JStarck, JGuillouzic, ADe Nanteuil, G Isoindoline or isoquinoline compounds, a process for their preparation and pharmaceutical compositions containing them US Patent  US9809574 Publication Date 11/7/2017 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM354624
Synonyms:
3-[2-(Dimethylcarbamoyl)ethyl]phenyl 6-{4-[(4-hydroxyphenyl)(methyl)carbamoyl]-1,5-dimethyl-1H-pyrrol-2-yl}-7-[(3R)-3-methyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]-1,2,3,4-tetrahydroisoquinoline-2-carboxylate | US9809574, Example 776
Type:
Small organic molecule
Emp. Form.:
C46H49N5O6
Mol. Mass.:
767.9112
SMILES:
C[C@@H]1Cc2ccccc2CN1C(=O)c1cc2CN(CCc2cc1-c1cc(C(=O)N(C)c2ccc(O)cc2)c(C)n1C)C(=O)Oc1cccc(CCC(=O)N(C)C)c1
Structure:
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