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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Ligand
BDBM354687
Substrate
n/a
Meas. Tech.
HTRF assay
IC50
5.5±n/a nM
Citation
 Armani, E; Amari, G; Blackaby, W; Van De Poel, H; Baker-Glenn, C; Trivedi, N Aminoester derivatives US Patent  US9809582 Publication Date 11/7/2017 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Synonyms:
3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B)
Type:
Protein
Mol. Mass.:
83318.87
Organism:
Homo sapiens (Human)
Description:
Q07343
Residue:
736
Sequence:
MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
  
Inhibitor
Name:
BDBM354687
Synonyms:
US9809582, Example 32 | US9809582, Example 34 | US9809582, Example 35
Type:
Small organic molecule
Emp. Form.:
C38H41Cl2N3O7S
Mol. Mass.:
754.719
SMILES:
COc1ccc(cc1OC)[C@H](Cc1c(Cl)c[n+]([O-])cc1Cl)OC(=O)c1ccc(CNC2CC(C2)(C(=O)OC2CCN(C)CC2)c2ccccc2)s1 |r,wU:10.22,(-8.04,-9.05,;-6.71,-9.82,;-5.37,-9.05,;-4.04,-9.82,;-2.7,-9.05,;-2.7,-7.51,;-4.04,-6.74,;-5.37,-7.51,;-6.71,-6.74,;-8.04,-7.51,;-1.37,-6.74,;-.04,-7.51,;1.3,-6.74,;1.3,-5.2,;-.04,-4.43,;2.63,-4.43,;3.96,-5.2,;5.3,-4.43,;3.96,-6.74,;2.63,-7.51,;2.63,-9.05,;-1.37,-5.2,;-2.7,-4.43,;-4.04,-5.2,;-2.7,-2.89,;-3.95,-1.98,;-3.47,-.52,;-1.93,-.52,;-1.03,.73,;-1.66,2.14,;-.89,3.47,;.6,3.87,;.2,5.35,;-1.28,4.96,;1.69,4.96,;2.78,6.05,;2.09,3.47,;3.58,3.07,;3.98,1.58,;5.46,1.18,;6.55,2.27,;8.04,1.87,;6.15,3.76,;4.67,4.16,;-.2,6.84,;.89,7.93,;.49,9.42,;-.99,9.82,;-2.08,8.73,;-1.68,7.24,;-1.46,-1.98,)|
Structure:
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