Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM354903
Substrate
n/a
Meas. Tech.
cAMP Assay
EC50
>4000±n/a nM
Citation
 Macielag, MJ; Zhang, Y; Greco, MN; Springer, BA; Murray, WV Chemically modified quinoline and quinolone derivatives useful as CB-1 inverse agonists US Patent  US9815790 Publication Date 11/14/2017 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM354903
Synonyms:
US9815790, 18
Type:
Small organic molecule
Emp. Form.:
C122H176Cl4F6N8O36S2
Mol. Mass.:
2650.667
SMILES:
FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1ccnc2c(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)NCCCOCCOCCOCCOCCCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOc3cc(cc4c(NC5CCN(CC5)S(=O)(=O)C(F)(F)F)ccnc34)C(c3ccc(Cl)cc3)c3ccc(Cl)cc3)cc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Structure:
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