Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM355650
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
115±n/a nM
Citation
 Altmann, E; Hommel, U; Lorthiois, EL; Maibaum, JK; Ostermann, N; Quancard, J; Randl, SA; Rogel, O; Vulpetti, A Complement pathway modulators and uses thereof US Patent  US9815819 Publication Date 11/14/2017 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM355650
Synonyms:
5-Methyl-1-{2-oxo-2-[(1R,3S,5R)-3- ((1R,2S)-2-phenyl- cyclopropylcarbamoyl)-2-aza- bicyclo[3.1.0]hex-2-yl]-ethyl}-1H- pyrazolo[3,4-]pyridine-3-carboxylic acid amide | US9815819, 15
Type:
Small organic molecule
Emp. Form.:
C25H26N6O3
Mol. Mass.:
458.5123
SMILES:
Cc1cc2c(nn(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)N[C@@H]3C[C@H]3c3ccccc3)c2cn1)C(N)=O |r|
Structure:
Search PDB for entries with ligand similarity: