Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM355663
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
172±n/a nM
Citation
 Altmann, E; Hommel, U; Lorthiois, EL; Maibaum, JK; Ostermann, N; Quancard, J; Randl, SA; Rogel, O; Vulpetti, A Complement pathway modulators and uses thereof US Patent  US9815819 Publication Date 11/14/2017 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM355663
Synonyms:
(1R,3S,5S)-2-[2-(3-Acetyl-pyrazolo[3,4-b]pyridin-1-yl)-acetyl]-5-hydroxymethyl-2-aza-bicyclo[3.1.0]hexane-3-carboxylic acid((1R,2S)-2-phenyl-cyclopropyl)-amide | US9815819, 28
Type:
Small organic molecule
Emp. Form.:
C26H27N5O4
Mol. Mass.:
473.5237
SMILES:
CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@]3(CO)C[C@H]2C(=O)N[C@@H]2C[C@H]2c2ccccc2)c2ncccc12 |r|
Structure:
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