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Target
Complement factor D
Ligand
BDBM355704
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
764±n/a nM
Citation
 Altmann, E; Hommel, U; Lorthiois, EL; Maibaum, JK; Ostermann, N; Quancard, J; Randl, SA; Rogel, O; Vulpetti, A Complement pathway modulators and uses thereof US Patent  US9815819 Publication Date 11/14/2017 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM355704
Synonyms:
1-(2-{(1R,3S,5R)-3-[(1S,2R)-2-(2- Chloro-phenyl)- cyclopropylcarbamoyl]-2-aza- bicyclo[3.1.0]hex-2-yl}-2-oxo- ethyl)-1H-indazole-3-carboxylic acid amide | US9815819, 69
Type:
Small organic molecule
Emp. Form.:
C25H24ClN5O3
Mol. Mass.:
477.943
SMILES:
NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@H]2C[C@@H]2c2ccccc2Cl)c2ccccc12 |r|
Structure:
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