Reaction Details Report a problem with these data
Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Ligand
BDBM355766
Substrate
n/a
Meas. Tech.
Scintillation Proximity Assay (SPA)
IC50
927±n/a nM
Citation
 Chappie, TA; Verhoest, PR; Patel, NC; Hayward, MM Azabenzimidazole compounds US Patent  US9815832 Publication Date 11/14/2017 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Synonyms:
3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B)
Type:
Protein
Mol. Mass.:
83318.87
Organism:
Homo sapiens (Human)
Description:
Q07343
Residue:
736
Sequence:
MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
  
Inhibitor
Name:
BDBM355766
Synonyms:
N-Cyclopropyl-3-(2,4-difluorophenyl)-3H-imidazo[4,5-b]pyridine-2-carboxamide | US9815832, 43
Type:
Small organic molecule
Emp. Form.:
C16H12F2N4O
Mol. Mass.:
314.2895
SMILES:
Fc1ccc(c(F)c1)-n1c(nc2cccnc12)C(=O)NC1CC1 |(.62,4.65,;.22,3.16,;1.31,2.07,;.91,.59,;-.58,.19,;-1.67,1.28,;-3.16,.88,;-1.27,2.76,;-.98,-1.3,;-.07,-2.55,;-.98,-3.79,;-2.44,-3.32,;-3.78,-4.09,;-5.11,-3.32,;-5.11,-1.78,;-3.78,-1.01,;-2.44,-1.78,;1.47,-2.55,;2.24,-1.21,;2.24,-3.88,;3.78,-3.88,;5.11,-4.65,;5.11,-3.11,)|
Structure:
Search PDB for entries with ligand similarity: