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Target
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Ligand
BDBM355929
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
0.004±n/a nM
Citation
 Soldermann, CP; Quancard, J; Schlapbach, A; Simic, O; Tintelnot-Blomley, M; Zoller, T Pyrazolo pyrimidine derivatives and their use as MALT1 inhibitors US Patent  US9815842 Publication Date 11/14/2017 
Target
Name:
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Synonyms:
MALT lymphoma-associated translocation | MALT lymphoma-associated translocation (MALT1) | MALT1 | MALT1_HUMAN | MLT | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Paracaspase
Type:
Enzyme
Mol. Mass.:
92257.81
Organism:
Homo sapiens (Human)
Description:
Q9UDY8
Residue:
824
Sequence:
MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAELAGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIGRTDEAVECTEDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCSRTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
  
Inhibitor
Name:
BDBM355929
Synonyms:
1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-yl)-3-(2- chloro-7-(2- methoxyphenyl)pyra- zolo[1,5-a]pyrimidin- 6-yl)urea | US10442808, Example 53 | US9815842, Example 53
Type:
Small organic molecule
Emp. Form.:
C21H15Cl2N9O2
Mol. Mass.:
496.309
SMILES:
COc1ccccc1-c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12 |(-7.9,2.55,;-6.57,1.78,;-5.23,2.55,;-5.23,4.09,;-3.9,4.86,;-2.56,4.09,;-2.56,2.55,;-3.9,1.78,;-3.9,.24,;-2.56,-.53,;-1.23,.24,;.1,-.53,;.1,-2.07,;1.44,.24,;2.77,-.53,;2.77,-2.07,;4.1,-2.84,;5.44,-2.07,;5.44,-.53,;6.77,.24,;4.1,.24,;6.77,-2.84,;6.77,-4.38,;8.24,-4.86,;9.14,-3.61,;8.24,-2.37,;-2.56,-2.07,;-3.9,-2.84,;-5.23,-2.07,;-6.7,-2.55,;-7.6,-1.3,;-9.14,-1.3,;-6.7,-.06,;-5.23,-.53,)|
Structure:
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