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TargetML-IAP-BIR
LigandBDBM17341
Substrate/CompetitorBDBM17342
Meas. Tech.Fluorescence Polarization Affinity Measurements.
pH7.2±n/a
Temperature295.15±n/a K
Ki 500±n/a nM
Citation Zobel, KWang, LVarfolomeev, EFranklin, MCElliott, LOWallweber, HJOkawa, DCFlygare, JAVucic, DFairbrother, WJDeshayes, K Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs. ACS Chem Biol1:525-33 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
ML-IAP-BIR
Name:ML-IAP-BIR
Synonyms:Chimeric protein of melanoma inhibitor of apoptosis protein and XIAP-BIR3 | MLXBIR3SG
Type:Chimeric Protein
Mol. Mass.:19011.07
Organism:Homo sapiens (Human)
Description:Amino acids 160-179 of MLBIR were replaced with amino acids 336-348 of XIAP-BIR3, and Ser150 of MLBIR was mutated to glycine to give MLXBIR3SG.
Residue:172
Sequence:
MGPKDSAKCLHRGPQPSHWAAGDGPTQERCGPRSLGSPVLGLDTCRAWDHVDGQILGQLR
PLTEEEEEEGAGATLSRGPAFPGMGSEELRLASFYDWPLTAEVPPELLAAAGFFHTGHQD
KVRCFFCYGGLQSWKRGDDPWTEHAKWFPGCQFLLRSKGQEYINNIHLTHSL
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BDBM17341
NameBDBM17341
Synonyms:(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S,3S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-aminopropanamido]-3-methylbutanoyl]pyrrolidin-2-yl]formamido}-3-methylpentanamido]propanamido]pentanediamido]hexanamido]-3-hydroxypropanamido]pentanedioic acid | AVPIAQKSE | L-alanyl-L-valyl-L-prolyl-L-isoleucyl-L-alanyl-L-glutaminyl-L-lysyl-L-seryl-L-glutamic acid
Typepolypeptide
Emp. Form.C41H71N11O14
Mol. Mass.942.0677
SMILESCC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(O)=O |r|
Structure
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BDBM17342
NameBDBM17342
Synonyms:5-carboxyflourescein(5-FAM)-conjugated AVPFFAKK | AVP-diPhe-FAM
TypeFluorescent dye-conjugated peptide
Emp. Form.n/a
Mol. Mass.n/a
SMILESn/a
Structure