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Target
Receptor-interacting serine/threonine-protein kinase 1
Ligand
BDBM356479
Substrate
n/a
Meas. Tech.
Fluorescent Polarization Binding (FP Binding) assay
IC50
500±n/a nM
Citation
 Estrada, AA; Feng, JA; Fox, B; Leslie, CP; Lyssikatos, JP; Pozzan, A; Sweeney, ZK; de Vicente Fidalgo, J Compounds, compositions and methods US Patent  US9815850 Publication Date 11/14/2017 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 1
Synonyms:
Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
75926.99
Organism:
Homo sapiens (Human)
Description:
Q13546
Residue:
671
Sequence:
MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPFAQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLDPGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQIGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN
  
Inhibitor
Name:
BDBM356479
Synonyms:
US10604535, Example 214 | US9815850, Compound 214 | US9896458, No. 214
Type:
Small organic molecule
Emp. Form.:
C20H17F2N5O3
Mol. Mass.:
413.3775
SMILES:
CN1c2ccccc2OC[C@H](NC(=O)c2nn(Cc3ccc(F)cn3)cc2F)C1=O |r|
Structure:
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