Reaction Details Report a problem with these data
Target
Methionine aminopeptidase 2
Ligand
BDBM17588
Substrate
Octapeptide substrate
Meas. Tech.
MetAP Enzyme Activity Assay
pH
7.4±n/a
Temperature
295.15±n/a K
IC50
1100±n/a nM
Citation
 Wang, J; Sheppard, GS; Lou, P; Kawai, M; BaMaung, N; Erickson, SA; Tucker-Garcia, L; Park, C; Bouska, J; Wang, YC; Frost, D; Tapang, P; Albert, DH; Morgan, SJ; Morowitz, M; Shusterman, S; Maris, JM; Lesniewski, R; Henkin, J Tumor suppression by a rationally designed reversible inhibitor of methionine aminopeptidase-2. Cancer Res 63:7861-9 (2003) [PubMed] 
Target
Name:
Methionine aminopeptidase 2
Synonyms:
Initiation factor 2-associated 67 kDa glycoprotein | MAP 2 | MAP2_HUMAN | METAP2 | MNPEP | MetAP 2 | Methionine aminopeptidase 2 (MetAP2) | Methionine aminopeptidases (HsMetAP2) | P67EIF2 | Peptidase M 2 | p67
Type:
Enzyme
Mol. Mass.:
52884.45
Organism:
Homo sapiens (Human)
Description:
P50579
Residue:
478
Sequence:
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
  
Inhibitor
Name:
BDBM17588
Synonyms:
bestatin-type inhibitor, 3 | ethyl (2S)-2-[(2S,3S)-3-amino-2-hydroxy-4-[(2-methylpropyl)sulfanyl]butanamido]propanoate
Type:
Small organic molecule
Emp. Form.:
C13H26N2O4S
Mol. Mass.:
306.422
SMILES:
CCOC(=O)[C@H](C)NC(=O)[C@@H](O)[C@H](N)CSCC(C)C |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Octapeptide substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
819.07
Organism:
n/a
Description:
n/a
Residue:
8
Sequence:
MGKVKVGV