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Target
Methionine aminopeptidase 2
Ligand
BDBM17608
Substrate
Octapeptide substrate
Meas. Tech.
MetAP2 Enzyme Activity Assay
pH
7.4±n/a
Temperature
295.15±n/a K
IC50
27±n/a nM
Citation
 Kawai, M; BaMaung, NY; Fidanze, SD; Erickson, SA; Tedrow, JS; Sanders, WJ; Vasudevan, A; Park, C; Hutchins, C; Comess, KM; Kalvin, D; Wang, J; Zhang, Q; Lou, P; Tucker-Garcia, L; Bouska, J; Bell, RL; Lesniewski, R; Henkin, J; Sheppard, GS Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties. Bioorg Med Chem Lett 16:3574-7 (2006) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase 2
Synonyms:
Initiation factor 2-associated 67 kDa glycoprotein | MAP 2 | MAP2_HUMAN | METAP2 | MNPEP | MetAP 2 | Methionine aminopeptidase 2 (MetAP2) | Methionine aminopeptidases (HsMetAP2) | P67EIF2 | Peptidase M 2 | p67
Type:
Enzyme
Mol. Mass.:
52884.45
Organism:
Homo sapiens (Human)
Description:
P50579
Residue:
478
Sequence:
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
  
Inhibitor
Name:
BDBM17608
Synonyms:
(8S)-2-[(4-fluorobenzene)sulfonamido]-8-methyl-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid | sulfonamide compound, 14
Type:
Small organic molecule
Emp. Form.:
C18H18FNO4S
Mol. Mass.:
363.403
SMILES:
C[C@H]1CCCc2ccc(NS(=O)(=O)c3ccc(F)cc3)c(C(O)=O)c12 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Octapeptide substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
819.07
Organism:
n/a
Description:
n/a
Residue:
8
Sequence:
MGKVKVGV