Target
Coagulation factor X
Ligand
BDBM17654
Substrate
BDBM17640
Meas. Tech.
In Vitro Assay for Inhibition of Factor Xa
pH
7.4±n/a
Temperature
295.15±n/a K
Ki
2±1 nM
Citation
 Chan, CBorthwick, ADBrown, DBurns-Kurtis, CLCampbell, MChaudry, LChung, CWConvery, MAHamblin, JNJohnstone, LKelly, HAKleanthous, SPatikis, APatel, CPateman, AJSenger, SShah, GPToomey, JRWatson, NSWeston, HEWhitworth, CYoung, RJZhou, P Factor Xa inhibitors: S1 binding interactions of a series of N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamides. J Med Chem 50:1546-57 (2007) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM17654
Synonyms:
5-(5-chlorothiophen-2-yl)-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]-1,3-thiazole-2-sulfonamide | N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1w
Type:
Small organic molecule
Emp. Form.:
C18H21ClN4O5S3
Mol. Mass.:
505.031
SMILES:
C[C@H](N1CC[C@H](NS(=O)(=O)c2ncc(s2)-c2ccc(Cl)s2)C1=O)C(=O)N1CCOCC1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM17640
Synonyms:
rhodamime 110, bis-(Boc-L-glycylglycyl-L-arginine amide)
Type:
n/a
Emp. Form.:
C70H86N14O13
Mol. Mass.:
1331.5178
SMILES:
CCC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)Nc1ccc2c(Oc3cc(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]4CCCN4C(=O)[C@@H](NC(=O)OCc4ccccc4)C(C)CC)ccc3C22OC(=O)c3ccccc23)c1 |r|
Structure:
Search PDB for entries with ligand similarity: