Reaction Details Report a problem with these data
Target
Glutamate carboxypeptidase 2 [44-750]
Ligand
BDBM17661
Substrate
BDBM17658
Meas. Tech.
Determination of Inhibition Concentration Values (IC50)
pH
7.4±n/a
Temperature
310.15±n/a K
IC50
67000±n/a nM
Citation
 Barinka, C; Rovenská, M; Mlcochová, P; Hlouchová, K; Plechanovová, A; Majer, P; Tsukamoto, T; Slusher, BS; Konvalinka, J; Lubkowski, J Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II. J Med Chem 50:3267-73 (2007) [PubMed]  Article 
Target
Name:
Glutamate carboxypeptidase 2 [44-750]
Synonyms:
FOLH | FOLH1 | FOLH1_HUMAN | Folate hydrolase 1 | Folylpoly-gamma-glutamate carboxypeptidase | Glutamate Carboxypeptidase II (GCPII) | Glutamate carboxypeptidase 2 | Membrane glutamate carboxypeptidase | NAALAD1 | PSM | PSMA | Prostate-specific membrane antigen | Prostate-specific membrane antigen (PSMA) | Pteroylpoly-gamma-glutamate carboxypeptidase | mGCP
Type:
Enzyme
Mol. Mass.:
79524.51
Organism:
Homo sapiens (Human)
Description:
The extracellular domain of human glutamate carboxypeptidase II (rhGCPII, amino acids 44-750) was overexpressed in Drosophila Schneider S2 cells and purified to homogeneity.
Residue:
707
Sequence:
KSSNEATNITPKHNMKAFLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLLSYPNKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDLVYVNYARTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADYFAPGVKSYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIPVHPIGYYDAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIGTLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEGWRPRRTILFASWDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVHNLTKELKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKNWETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDYAVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIVLRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVDPSKAWGEVKRQIYVAAFTVQAAAETLSEVA
  
Inhibitor
Name:
BDBM17661
Synonyms:
(2S)-2-amino-3-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)propanoic acid | 2-amino-3-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)propionic acid | CHEMBL122005 | willardiine
Type:
Small organic molecule
Emp. Form.:
C7H9N3O4
Mol. Mass.:
199.1641
SMILES:
N[C@@H](Cn1ccc(=O)[nH]c1=O)C(O)=O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM17658
Synonyms:
(2S)-2-[(3S)-3-acetamido-3-formamidopropanoic acid]pentanedioic acid | N-acetylaspartylglutamate (NAAG) | NAAG | [3H]NAAG
Type:
Small organic molecule
Emp. Form.:
C11H16N2O8
Mol. Mass.:
304.2533
SMILES:
CC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O |r|
Structure:
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