Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM60828
Substrate
n/a
Meas. Tech.
TR-FRET (Time-Resolved Fluorescence-Resonance-Energy-Transfer) assay
Ki
<0.010±n/a nM
Citation
 Catron, N; Lindley, D; Miller, JM; Schmitt, EA; Tong, P Solid dispersions containing an apoptosis-inducing agent US Patent  US10213433 Publication Date 2/26/2019 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM60828
Synonyms:
ABT-199 | BDBM189459 | US10213433, Compound 5 | US10377755, Example ABT-199 | US11318134, Example ABT-199 | US11369599, Compound 369 | US11590126, Example ABT-199 | US11718611, Example T-7 | US20240043404, Example 369 | US9174982, 369
Type:
n/a
Emp. Form.:
C45H50ClN7O7S
Mol. Mass.:
868.439
SMILES:
CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |c:57|
Structure:
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