Reaction Details Report a problem with these data
Target
Period circadian protein homolog 2
Ligand
BDBM356661
Substrate
n/a
Meas. Tech.
Per2 Assay
EC50
816±n/a nM
Citation
 Bersot, R; Humphries, P Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators US Patent  US10214507 Publication Date 2/26/2019 
Target
Name:
Period circadian protein homolog 2
Synonyms:
Circadian clock protein PERIOD 2 | KIAA0347 | PER2 | PER2_HUMAN | Period circadian protein homolog 2 | hPER2
Type:
PROTEIN
Mol. Mass.:
136576.47
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116705
Residue:
1255
Sequence:
MNGYAEFPPSPSNPTKEPVEPQPSQVPLQEDVDMSSGSSGHETNENCSTGRDSQGSDCDDSGKELGMLVEPPDARQSPDTFSLMMAKSEHNPSTSGCSSDQSSKVDTHKELIKTLKELKVHLPADKKAKGKASTLATLKYALRSVKQVKANEEYYQLLMSSEGHPCGADVPSYTVEEMESVTSEHIVKNADMFAVAVSLVSGKILYISDQVASIFHCKRDAFSDAKFVEFLAPHDVGVFHSFTSPYKLPLWSMCSGADSFTQECMEEKSFFCRVSVRKSHENEIRYHPFRMTPYLVKVRDQQGAESQLCCLLLAERVHSGYEAPRIPPEKRIFTTTHTPNCLFQDVDERAVPLLGYLPQDLIETPVLVQLHPSDRPLMLAIHKKILQSGGQPFDYSPIRFRARNGEYITLDTSWSSFINPWSRKISFIIGRHKVRVGPLNEDVFAAHPCTEEKALHPSIQELTEQIHRLLLQPVPHSGSSGYGSLGSNGSHEHLMSQTSSSDSNGHEDSRRRRAEICKNGNKTKNRSHYSHESGEQKKKSVTEMQTNPPAEKKAVPAMEKDSLGVSFPEELACKNQPTCSYQQISCLDSVIRYLESCNEAATLKRKCEFPANVPALRSSDKRKATVSPGPHAGEAEPPSRVNSRTGVGTHLTSLALPGKAESVASLTSQCSYSSTIVHVGDKKPQPELEMVEDAASGPESLDCLAGPALACGLSQEKEPFKKLGLTKEVLAAHTQKEEQSFLQKFKEIRKLSIFQSHCHYYLQERSKGQPSERTAPGLRNTSGIDSPWKKTGKNRKLKSKRVKPRDSSESTGSGGPVSARPPLVGLNATAWSPSDTSQSSCPAVPFPAPVPAAYSLPVFPAPGTVAAPPAPPHASFTVPAVPVDLQHQFAVQPPPFPAPLAPVMAFMLPSYSFPSGTPNLPQAFFPSQPQFPSHPTLTSEMASASQPEFPSRTSIPRQPCACPATRATPPSAMGRASPPLFQSRSSSPLQLNLLQLEEAPEGGTGAMGTTGATETAAVGADCKPGTSRDQQPKAPLTRDEPSDTQNSDALSTSSGLLNLLLNEDLCSASGSAASESLGSGSLGCDASPSGAGSSDTSHTSKYFGSIDSSENNHKAKMNTGMEESEHFIKCVLQDPIWLLMADADSSVMMTYQLPSRNLEAVLKEDREKLKLLQKLQPRFTESQKQELREVHQWMQTGGLPAAIDVAECVYCENKEKGNICIPYEEDIPSLGLSEVSDTKEDENGSPLNHRIEEQT
  
Inhibitor
Name:
BDBM356661
Synonyms:
1-cyclobutyl-3-(3- (3,6-difluoro-9H- carbazol-9-yl)-2- hydroxy-2- methylpropyl)tetra- hydropyrimidin- 2(1H)-one | US10214507, Compound 81 | US10759777, Compound 81
Type:
Small organic molecule
Emp. Form.:
C24H27F2N3O2
Mol. Mass.:
427.4869
SMILES:
CC(O)(CN1CCCN(C2CCC2)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12
Structure:
Search PDB for entries with ligand similarity: