Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM242373
Substrate
n/a
Meas. Tech.
Pim-1 Kinase Inhibition Assay
Temperature
298.15±n/a K
IC50
103±n/a nM
Comments
extracted
Citation
 Xu, Y; Brenning, BG; Kultgen, SG; Liu, X; Saunders, MD; Ho, K Substituted imidazo[1,2-B]pyridazines as protein kinase inhibitors US Patent  US10047093 Publication Date 8/14/2018 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM242373
Synonyms:
US10047093, 8-30 | US10392392, Example 8-30 | US10875864, EX. 8-30 | US9416132, 8-30
Type:
Small organic molecule
Emp. Form.:
C20H21F3N4O
Mol. Mass.:
390.4021
SMILES:
C[C@]1(O)CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(c3)C(F)(F)F)n2n1 |r,wU:5.8,1.0,wD:1.1,(-7.36,4.3,;-6.59,2.97,;-8.13,2.97,;-6.59,1.43,;-5.26,.66,;-3.93,1.43,;-3.93,2.97,;-5.26,3.74,;-2.59,.66,;-1.26,1.43,;-1.26,2.97,;.08,3.74,;1.41,2.97,;2.87,3.45,;3.78,2.2,;2.87,.96,;3.27,-.53,;2.18,-1.62,;2.58,-3.11,;4.07,-3.51,;5.25,-2.41,;4.76,-.93,;6.75,-2.79,;8.24,-3.17,;6.36,-4.28,;7.13,-1.3,;1.41,1.43,;.08,.66,)|
Structure:
Search PDB for entries with ligand similarity: