Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM242405
Substrate
n/a
Meas. Tech.
Pim-1 Kinase Inhibition Assay
Temperature
298.15±n/a K
IC50
38.0±n/a nM
Comments
extracted
Citation
 Xu, Y; Brenning, BG; Kultgen, SG; Liu, X; Saunders, MD; Ho, K Substituted imidazo[1,2-B]pyridazines as protein kinase inhibitors US Patent  US10047093 Publication Date 8/14/2018 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM242405
Synonyms:
US10047093, 8-92 | US10392392, Example 8-92 | US10875864, EX. 8-92 | US9416132, 8-92
Type:
Small organic molecule
Emp. Form.:
C18H18ClN5O
Mol. Mass.:
355.821
SMILES:
[#8]\[#7]=[#6]-1\[#6]-[#6]-[#6](-[#6]-[#6]-1)-[#7]-c1ccc2ncc(-c3cccc(Cl)c3)n2n1
Structure:
Search PDB for entries with ligand similarity: