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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM228389
Substrate
n/a
Meas. Tech.
Pim-1 Kinase Inhibition Assay
Temperature
298.15±n/a K
IC50
518±n/a nM
Comments
extracted
Citation
 Xu, Y; Brenning, BG; Kultgen, SG; Liu, X; Saunders, MD; Ho, K Substituted imidazo[1,2-B]pyridazines as protein kinase inhibitors US Patent  US10047093 Publication Date 8/14/2018 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM228389
Synonyms:
US10047093, 8-106 | US10392392, Example 8-106 | US10875864, EX. 8-106
Type:
Small organic molecule
Emp. Form.:
C20H21F3N4O
Mol. Mass.:
390.4021
SMILES:
OC[C@H]1CC[C@@H](CC1)Nc1ccc2nnc(-c3cccc(c3)C(F)(F)F)n2c1 |r,wU:2.1,wD:5.8,(-7.41,5.59,;-7.41,4.05,;-6.08,3.28,;-4.7,4.02,;-3.36,3.25,;-3.36,1.71,;-4.7,.94,;-6.03,1.71,;-2.03,.94,;-.69,1.71,;-.69,3.25,;.64,4.02,;1.97,3.25,;3.44,3.73,;4.34,2.48,;3.44,1.24,;3.84,-.25,;2.75,-1.34,;3.15,-2.83,;4.63,-3.23,;5.78,-2.15,;5.32,-.65,;7.26,-2.55,;8.75,-2.95,;6.86,-4.04,;7.66,-1.06,;1.97,1.71,;.64,.94,)|
Structure:
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