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Target
Phosphatidylinositol 3-kinase regulatory subunit beta
Ligand
BDBM357275
Substrate
n/a
Meas. Tech.
TR-FRET PI3K Beta Assay
IC50
4.00±n/a nM
Citation
 Chandrasekhar, J; Codelli, JA; Naduthambi, D; Patel, L; Perreault, S; Phillips, G; Sedillo, KF; Treiberg, JA; Van Veldhuizen, J; Watkins, WJ Phosphatidylinositol 3-kinase inhibitors US Patent  US10214519 Publication Date 2/26/2019 
Target
Name:
Phosphatidylinositol 3-kinase regulatory subunit beta
Synonyms:
P85B_HUMAN | PI3-kinase regulatory subunit beta | PI3-kinase subunit p85-beta | PI3K regulatory subunit beta | PIK3R2 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta | PtdIns-3-kinase regulatory subunit beta | PtdIns-3-kinase regulatory subunit p85-beta
Type:
Enzyme Subunit
Mol. Mass.:
81542.75
Organism:
Homo sapiens (Human)
Description:
O00459
Residue:
728
Sequence:
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR
  
Inhibitor
Name:
BDBM357275
Synonyms:
US10214519, Example 1
Type:
Small organic molecule
Emp. Form.:
C25H24ClN7O
Mol. Mass.:
473.957
SMILES:
CCCc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)N1CCOCC1)-c1nnc[nH]1 |(6.78,-.61,;5.29,-1.01,;4.2,.08,;2.71,-.32,;2.24,-1.78,;.7,-1.78,;-.33,-2.93,;-1.84,-2.61,;-2.32,-1.14,;-1.28,0,;.22,-.32,;1.47,.59,;1.47,2.13,;2.8,2.9,;2.8,4.44,;1.47,5.21,;.13,4.44,;-1.2,5.21,;-1.2,6.75,;-2.53,4.44,;-2.53,2.9,;-1.2,2.13,;.13,2.9,;-3.8,-.74,;-4.2,.74,;-5.69,1.14,;-6.78,.05,;-6.38,-1.43,;-4.89,-1.83,;.44,-4.26,;-.4,-5.55,;.57,-6.75,;2.01,-6.2,;1.92,-4.66,)|
Structure:
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