Reaction Details Report a problem with these data
Target
Phosphatidylinositol 3-kinase regulatory subunit beta
Ligand
BDBM357440
Substrate
n/a
Meas. Tech.
TR-FRET PI3K Beta Assay
IC50
7.00±n/a nM
Citation
 Chandrasekhar, J; Codelli, JA; Naduthambi, D; Patel, L; Perreault, S; Phillips, G; Sedillo, KF; Treiberg, JA; Van Veldhuizen, J; Watkins, WJ Phosphatidylinositol 3-kinase inhibitors US Patent  US10214519 Publication Date 2/26/2019 
Target
Name:
Phosphatidylinositol 3-kinase regulatory subunit beta
Synonyms:
P85B_HUMAN | PI3-kinase regulatory subunit beta | PI3-kinase subunit p85-beta | PI3K regulatory subunit beta | PIK3R2 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta | PtdIns-3-kinase regulatory subunit beta | PtdIns-3-kinase regulatory subunit p85-beta
Type:
Enzyme Subunit
Mol. Mass.:
81542.75
Organism:
Homo sapiens (Human)
Description:
O00459
Residue:
728
Sequence:
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR
  
Inhibitor
Name:
BDBM357440
Synonyms:
US10214519, Example 170
Type:
Small organic molecule
Emp. Form.:
C23H18Cl2FN7O
Mol. Mass.:
498.34
SMILES:
Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)ccc(F)c12)N1CCOCC1)-c1nnc(Cl)[nH]1 |(-4.85,.39,;-3.36,-.01,;-2.81,-1.45,;-1.27,-1.37,;-.18,-2.45,;1.3,-2.06,;1.7,-.57,;.61,.52,;-.87,.12,;-2.16,.96,;-2.16,2.5,;-.83,3.27,;-.83,4.81,;-2.16,5.58,;-3.5,4.81,;-4.83,5.58,;-4.83,7.12,;-6.17,4.81,;-6.17,3.27,;-4.83,2.5,;-4.83,.96,;-3.5,3.27,;3.19,-.17,;4.28,-1.26,;5.77,-.86,;6.17,.63,;5.08,1.72,;3.59,1.32,;-.58,-3.94,;.39,-5.14,;-.45,-6.43,;-1.94,-6.03,;-3.03,-7.12,;-2.02,-4.49,)|
Structure:
Search PDB for entries with ligand similarity: