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Target
Phosphatidylinositol 3-kinase regulatory subunit beta
Ligand
BDBM357626
Substrate
n/a
Meas. Tech.
TR-FRET PI3K Beta Assay
IC50
9.00±n/a nM
Citation
 Chandrasekhar, J; Codelli, JA; Naduthambi, D; Patel, L; Perreault, S; Phillips, G; Sedillo, KF; Treiberg, JA; Van Veldhuizen, J; Watkins, WJ Phosphatidylinositol 3-kinase inhibitors US Patent  US10214519 Publication Date 2/26/2019 
Target
Name:
Phosphatidylinositol 3-kinase regulatory subunit beta
Synonyms:
P85B_HUMAN | PI3-kinase regulatory subunit beta | PI3-kinase subunit p85-beta | PI3K regulatory subunit beta | PIK3R2 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta | PtdIns-3-kinase regulatory subunit beta | PtdIns-3-kinase regulatory subunit p85-beta
Type:
Enzyme Subunit
Mol. Mass.:
81542.75
Organism:
Homo sapiens (Human)
Description:
O00459
Residue:
728
Sequence:
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR
  
Inhibitor
Name:
BDBM357626
Synonyms:
US10214519, Example 392
Type:
Small organic molecule
Emp. Form.:
C25H22N10O
Mol. Mass.:
478.5086
SMILES:
Cc1nc2c(cc(cc2n1-c1c(cnc2ccccc12)-c1nnc[nH]1)N1CCOCC1)-c1nnc[nH]1 |(-4.7,1.28,;-3.37,.51,;-2.89,-.95,;-1.35,-.95,;-.32,-2.1,;1.18,-1.78,;1.66,-.31,;.63,.83,;-.88,.51,;-2.12,1.42,;-2.12,2.99,;-.79,3.76,;-.79,5.3,;-2.12,6.07,;-3.46,5.3,;-4.79,6.07,;-6.12,5.3,;-6.12,3.76,;-4.79,2.99,;-3.46,3.76,;.55,2.99,;.55,1.45,;2.01,.98,;2.91,2.22,;2.01,3.47,;3.15,.09,;4.24,-1,;5.72,-.6,;6.12,.88,;5.03,1.97,;3.55,1.58,;-.72,-3.58,;.18,-4.83,;-.72,-6.07,;-2.18,-5.6,;-2.18,-4.06,)|
Structure:
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