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Target
Glutamine--tRNA ligase
Ligand
BDBM18118
Substrate
BDBM17657
Meas. Tech.
Determination of the Inhibition Type and Constant (Ki)
pH
7.2±n/a
Temperature
310.15±n/a K
Ki
2600000±n/a nM
Comments
Binding competitively at two distinct sites.
Citation
 Balg, C; Blais, SP; Bernier, S; Huot, JL; Couture, M; Lapointe, J; Chênevert, R Synthesis of beta-ketophosphonate analogs of glutamyl and glutaminyl adenylate, and selective inhibition of the corresponding bacterial aminoacyl-tRNA synthetases. Bioorg Med Chem 15:295-304 (2007) [PubMed]  Article 
Target
Name:
Glutamine--tRNA ligase
Synonyms:
QARS | QARS1 | SYQ_BOVIN | tRNA synthetase (GluRS)
Type:
Enzyme
Mol. Mass.:
87647.72
Organism:
Bos taurus (bovine)
Description:
Partially purified fraction from bovine liver containing aaRS.
Residue:
775
Sequence:
MAALDSLSLFTGLGLSEQKARETLKNTVLSAQLREAATQAQQTLGSSIDKATGTLLYGLASRLRDPRRLSFLVSYITSRKIHTETQLSAALEYVRSHPLDPINTEDFEQECGVGVVVTPEQIEEAVEAAINRHRAKLLVERYHFSMGLLMGEARAALKWADGKMIKHEVDMQVLHLLGPKTETDLEKKPKVAKARPEETDQRTAKDVVENGEVVVQTLSLMEQLRGEALKFHKPGENYKTPGYVTTPHTMDLLKQHLDITGGQVRTRFPPEPNGILHIGHAKAINFNFGYAKANNGICFLRFDDTNPEKEEAKFFTAIYDMVAWLGYTPYKVTYASDYFDQLYAWAVELIRRDQAYVCHQRGEELKGHNPLPSPWRDRPIEESLLLFEAMRKGKFAEGEATLRMKLVMEDGKMDPVAYRVKYTPHHRTGDTWCIYPTYDYTHCLCDSIEHITHSLCTKEFQARRSSYFWLCNALDVYCPVQWEYGRLNLHYAVVSKRKILQLVAAGAVRDWDDPRLFTLTALRRRGFPPEAINNFCARVGVTVAQTTMEPHLLEACVRDVLNDTAPRAMAVLEPLQVVITNFPATKALDIQVPNFPADETKGFHQVPFGSTVFIERMDFKEEPEPGYKRLAWGQPVGLRHTGYVIELQHVVKGPSGCVESLKVTCRRADAGEKPKAFIHWVSQPLTCEIRLYERLFQHKNPEDPAEVPGGFLSDLNPASLQVVEAALVDCSVALAKPFDKFQFERLGYFSVDPDSNQGQLVFNRTVTLKEDPGKV
  
Inhibitor
Name:
BDBM18118
Synonyms:
(4S)-4-amino-6-({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)-5-oxohexanoic acid | Glu-KPA | beta-ketophosphonate analogue
Type:
Small organic molecule
Emp. Form.:
C16H23N6O9P
Mol. Mass.:
474.3624
SMILES:
N[C@@H](CCC(O)=O)C(=O)CP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM17657
Synonyms:
(2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutamate | Glutamate | L-Glu | L-Glutamate | L-Glutamic acid | L-[14C(U)]glutamate | L-gluatmate
Type:
Amino Acid
Emp. Form.:
C5H9NO4
Mol. Mass.:
147.1293
SMILES:
N[C@@H](CCC(O)=O)C(O)=O
Structure:
Search PDB for entries with ligand similarity: