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Target
Tryptophan 5-hydroxylase 1
Ligand
BDBM357742
Substrate
n/a
Meas. Tech.
In Vitro Enzyme Activity Assay
IC50
770±n/a nM
Citation
 Bader, M; Specker, E; Matthes, S; Schütz, A; Mallow, K; Grohmann, M; Nazaré, M Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same US Patent  US10214530 Publication Date 2/26/2019 
Target
Name:
Tryptophan 5-hydroxylase 1
Synonyms:
TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1
Type:
PROTEIN
Mol. Mass.:
50990.64
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1361824
Residue:
444
Sequence:
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI
  
Inhibitor
Name:
BDBM357742
Synonyms:
US10214530, LX1031 | US11028104, Example LX1031
Type:
Small organic molecule
Emp. Form.:
C28H25F3N4O4
Mol. Mass.:
538.5177
SMILES:
COc1cccc(c1)-c1ccc(cc1)[C@@H](Oc1cc(nc(N)n1)-c1ccc(CC(N)C(O)=O)cc1)C(F)(F)F |r|
Structure:
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