Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM357846
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
60.0±n/a nM
Citation
 Kuduk, SD; Liverton, N; Luo, Y Hydroxmethyl piperidine orexin receptor antagonists US Patent  US10214535 Publication Date 2/26/2019 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM357846
Synonyms:
US10214535, Example 6 | [(2S,5R)-5-{[4-(2,2- difluoroethoxy)pyridin-2-yl] oxy}-1-{[2-(2H-1,2,3-triazol-2- yl)phenyl]carbonyl}piperidin-2- yl]methanol
Type:
Small organic molecule
Emp. Form.:
C22H23F2N5O4
Mol. Mass.:
459.4459
SMILES:
OC[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)Oc1cc(OCC(F)F)ccn1 |r|
Structure:
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