Reaction Details Report a problem with these data
Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM357847
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
1781±n/a nM
Citation
 Kuduk, SD; Liverton, N; Luo, Y Hydroxmethyl piperidine orexin receptor antagonists US Patent  US10214535 Publication Date 2/26/2019 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM357847
Synonyms:
2-{[(3R,6S)-6-(hydroxymethyl)- 1-{[2-(2H-1,2,3-triazol-2-yl) phenyl]carbonyl}piperidin-3-yl] oxy}-3-methylpyridine-4- carbonitrile | US10214535, Example 7
Type:
Small organic molecule
Emp. Form.:
C22H22N6O3
Mol. Mass.:
418.4485
SMILES:
Cc1c(O[C@@H]2CC[C@@H](CO)N(C2)C(=O)c2ccccc2-n2nccn2)nccc1C#N |r|
Structure:
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