Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM357850
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
12.0±n/a nM
Citation
 Kuduk, SD; Liverton, N; Luo, Y Hydroxmethyl piperidine orexin receptor antagonists US Patent  US10214535 Publication Date 2/26/2019 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM357850
Synonyms:
US10214535, Example 10
Type:
Small organic molecule
Emp. Form.:
C22H25N3O5
Mol. Mass.:
411.451
SMILES:
CCOc1ccccc1C(=O)N1C[C@@H](CC[C@H]1CO)Oc1nccc(C#N)c1OC |r|
Structure:
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