Reaction Details Report a problem with these data
Target
Prostaglandin D2 receptor 2
Ligand
BDBM234939
Substrate
n/a
Meas. Tech.
Binding Inhibition Assay (4% HSA)
pH
7.4±n/a
Temperature
298.15±n/a K
EC50
16.2±n/a nM
Comments
extracted
Citation
 Burgess, LE; Clark, CT; Cook, A; Corrette, CP; DeLisle, RK; Doherty, GA; Hunt, KW; Romoff, TT; Kim, G 6-substituted phenoxychroman carboxylic acid derivatives US Patent  US9556139 Publication Date 1/31/2017 
Target
Name:
Prostaglandin D2 receptor 2
Synonyms:
CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:
Enzyme
Mol. Mass.:
43295.45
Organism:
Homo sapiens (Human)
Description:
Q9Y5Y4
Residue:
395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
  
Inhibitor
Name:
BDBM234939
Synonyms:
US9556139, 238 Enantiomer 2
Type:
Small organic molecule
Emp. Form.:
C27H23ClF3NO6
Mol. Mass.:
549.923
SMILES:
COc1cc(ccc1CCNC(=O)c1ccc(Oc2cc3OCC[C@@H](C(O)=O)c3cc2Cl)cc1)C(F)(F)F |r|
Structure:
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