Reaction Details Report a problem with these data
Target
Proteinase-activated receptor 4
Ligand
BDBM358787
Substrate
n/a
Meas. Tech.
FLIPR Assay in PAR4-Expressing HEK293 Cells
EC50
4.80±n/a nM
Citation
 Banville, J Imidazopyridazine and imidazothiadiazole compounds US Patent  US10214544 Publication Date 2/26/2019 
Target
Name:
Proteinase-activated receptor 4
Synonyms:
Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3
Type:
Protein
Mol. Mass.:
41145.16
Organism:
Homo sapiens (Human)
Description:
Q96RI0
Residue:
385
Sequence:
MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
  
Inhibitor
Name:
BDBM358787
Synonyms:
US10214544, Example 93
Type:
Small organic molecule
Emp. Form.:
C28H25N5O5S2
Mol. Mass.:
575.659
SMILES:
COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)N(C)C(=O)c3sc(C)nc3C)cc(OC)cc2o1
Structure:
Search PDB for entries with ligand similarity: