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Target
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a)
Ligand
BDBM358867
Substrate
n/a
Meas. Tech.
MKNK1 Kinase Assay
IC50
8.80±n/a nM
Citation
 Schulze, V; Eis, K; Puehler, F; Zorn, L; Sülzle, D; Lienau, P; Wengner, AM; Petersen, K; Bömer, U Amido-substituted imidazopyridazines useful in the treatment of hyper-proliferative and/or angiogenesis disorders US Patent  US10214545 Publication Date 2/26/2019 
Target
Name:
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a)
Synonyms:
MAP Kinase interacting Kinase | MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) | MKNK1 | MKNK1_HUMAN | MNK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
47403.02
Organism:
Homo sapiens (Human)
Description:
BAA19885
Residue:
424
Sequence:
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
  
Inhibitor
Name:
BDBM358867
Synonyms:
3-(1-Benzofuran-2-yl)-N-benzyl-N-methylimidazo[1,2-b]pyridazine-6-carboxamide | US10214545, Example 16
Type:
Small organic molecule
Emp. Form.:
C23H18N4O2
Mol. Mass.:
382.4146
SMILES:
CN(Cc1ccccc1)C(=O)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Structure:
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