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Target
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a)
Ligand
BDBM358860
Substrate
n/a
Meas. Tech.
MKNK1 Kinase High ATP Assay
IC50
4.50±n/a nM
Citation
 Schulze, V; Eis, K; Puehler, F; Zorn, L; Sülzle, D; Lienau, P; Wengner, AM; Petersen, K; Bömer, U Amido-substituted imidazopyridazines useful in the treatment of hyper-proliferative and/or angiogenesis disorders US Patent  US10214545 Publication Date 2/26/2019 
Target
Name:
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a)
Synonyms:
MAP Kinase interacting Kinase | MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) | MKNK1 | MKNK1_HUMAN | MNK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
47403.02
Organism:
Homo sapiens (Human)
Description:
BAA19885
Residue:
424
Sequence:
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
  
Inhibitor
Name:
BDBM358860
Synonyms:
N-[3-(dimethylamino)propyl]-3-[4-(morpholin-4-yl)furo[3,2-c]pyridin-2-yl]-imidazo[1,2-b]pyridazine-6-carboxamide | US10214545, Example 9
Type:
Small organic molecule
Emp. Form.:
C23H27N7O3
Mol. Mass.:
449.5056
SMILES:
CN(C)CCCNC(=O)c1ccc2ncc(-c3cc4c(nccc4o3)N3CCOCC3)n2n1
Structure:
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