Reaction Details Report a problem with these data
Target
Nuclear receptor ROR-gamma
Ligand
BDBM352905
Substrate
n/a
Meas. Tech.
biochemical TR-FRET assay
IC50
3.87±n/a nM
Citation
 Aicher, TD; VanHuis, CA; Thomas, WD; MacLean, JK; Andresen, BM; Barr, KJ; Bienstock, CE; Anthony, NJ; Daniels, M; Liu, K; Liu, Y; White, CM; Lapointe, BT; Sciammetta, N; Simov, V Tetrahydronaphthyridine, benzoxazine, aza-benzoxazine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease US Patent  US10221146 Publication Date 3/5/2019 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM352905
Synonyms:
2,2,2-trifluoro-1,1- dimethylethyl {l-[(3- chloro-1-ethyl-1H-pyrazol- 4-yl)sulfonyl]-1,2,3,4- tetrahydroquinolin-7- yl}carbamate | US10745364, Example 114A | US9809561, 114A | US9809561, 118
Type:
Small organic molecule
Emp. Form.:
C19H22ClF3N4O4S
Mol. Mass.:
494.916
SMILES:
CCn1cc(c(Cl)n1)S(=O)(=O)N1CCCc2ccc(NC(=O)OC(C)(C)C(F)(F)F)cc12
Structure:
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