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Target
Nuclear receptor ROR-gamma
Ligand
BDBM235003
Substrate
n/a
Meas. Tech.
Biological Assay
pH
7±n/a
IC50
4855±n/a nM
Comments
extracted
Citation
 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Anthony, NJ; Lapointe, BT; Sciammetta, N N-alkylated indole and indazole compounds as RORgammaT inhibitors and uses thereof US Patent  US9556168 Publication Date 1/31/2017 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM235003
Synonyms:
3-Fluoro-4-[4-fluoro-1-(2,5-difluorobenzyl)-1H-indazol-3-yl]benzoic acid (3A) | US9556168, 3A
Type:
Small organic molecule
Emp. Form.:
C21H12F4N2O2
Mol. Mass.:
400.3258
SMILES:
OC(=O)c1ccc(-c2nn(Cc3cc(F)ccc3F)c3cccc(F)c23)c(F)c1
Structure:
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