Reaction Details Report a problem with these data
Target
Kallikrein-1
Ligand
BDBM359662
Substrate
n/a
Meas. Tech.
KLK1 inhibitory activity
IC50
40000±n/a nM
Citation
 Edwards, HJ; Evans, DM; Meghani, P; Novak, AR Inhibitors of plasma kallikrein US Patent  US10221161 Publication Date 3/5/2019 
Target
Name:
Kallikrein-1
Synonyms:
KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein
Type:
Enzyme
Mol. Mass.:
28874.69
Organism:
Homo sapiens (Human)
Description:
P06870
Residue:
262
Sequence:
MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS
  
Inhibitor
Name:
BDBM359662
Synonyms:
N-[(1-Aminoisoquinolin-6-yl)methyl]-5-({4-[(1-methylpyrazol-4-yl)methyl]piperazin-1-yl}methyl)pyridine-3-carboxamide | US10221161, Example 47 | US11242333, Example 47
Type:
Small organic molecule
Emp. Form.:
C26H30N8O
Mol. Mass.:
470.5694
SMILES:
Cn1cc(CN2CCN(Cc3cncc(c3)C(=O)NCc3ccc4c(N)nccc4c3)CC2)cn1
Structure:
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