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Target
Kallikrein-1
Ligand
BDBM359703
Substrate
n/a
Meas. Tech.
KLK1 inhibitory activity
IC50
8540±n/a nM
Citation
 Edwards, HJ; Evans, DM; Meghani, P; Novak, AR Inhibitors of plasma kallikrein US Patent  US10221161 Publication Date 3/5/2019 
Target
Name:
Kallikrein-1
Synonyms:
KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein
Type:
Enzyme
Mol. Mass.:
28874.69
Organism:
Homo sapiens (Human)
Description:
P06870
Residue:
262
Sequence:
MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS
  
Inhibitor
Name:
BDBM359703
Synonyms:
N-[(1-Aminoisoquinolin-6-yl)methyl]-5-{[2-(morpholin-4-yl)pyridin-4-yl]methyl}pyridine-3-carboxamide | US10221161, Example 85 | US11242333, Example 85
Type:
Small organic molecule
Emp. Form.:
C26H26N6O2
Mol. Mass.:
454.5236
SMILES:
Nc1nccc2cc(CNC(=O)c3cncc(Cc4ccnc(c4)N4CCOCC4)c3)ccc12
Structure:
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