Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase BTK
Ligand
BDBM359873
Substrate
n/a
Meas. Tech.
KinaseProfiler Radiometric Protein Kinase Assay
EC50
<100±n/a nM
Citation
 Laurent, A; Rose, Y Protein kinase inhibitors US Patent  US9822120 Publication Date 11/21/2017 
Target
Name:
Tyrosine-protein kinase BTK
Synonyms:
AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:
Enzyme
Mol. Mass.:
76289.95
Organism:
Homo sapiens (Human)
Description:
Q06187
Residue:
659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
  
Inhibitor
Name:
BDBM359873
Synonyms:
US9822120, Compound 29
Type:
Small organic molecule
Emp. Form.:
C28H25FN6O3
Mol. Mass.:
512.5349
SMILES:
Cc1ncc(COc2cc(F)cc(Oc3ccc(cc3)-c3nc([C@@H]4C[C@H](O)C4)n4ccnc(N)c34)c2)cn1 |r,wU:23.23,25.26,(8.36,-.46,;7.27,.63,;5.78,.23,;4.7,1.32,;5.09,2.8,;4.01,3.89,;2.52,3.49,;1.43,4.58,;1.83,6.07,;.74,7.16,;1.14,8.65,;-.75,6.76,;-1.15,5.27,;-2.63,4.87,;-3.03,3.39,;-1.94,2.3,;-2.34,.81,;-3.83,.41,;-4.92,1.5,;-4.52,2.99,;-4.23,-1.08,;-3.32,-2.32,;-4.23,-3.57,;-3.83,-5.06,;-4.6,-6.39,;-3.27,-7.16,;-2.87,-8.65,;-2.5,-5.83,;-5.69,-3.09,;-7.03,-3.86,;-8.36,-3.09,;-8.36,-1.55,;-7.03,-.78,;-7.03,.76,;-5.69,-1.55,;-.06,4.18,;6.58,3.2,;7.67,2.11,)|
Structure:
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