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Target
Tyrosine-protein kinase BTK
Ligand
BDBM359860
Substrate
n/a
Meas. Tech.
Kinase Inhibition Assay
EC50
<100±n/a nM
Citation
 Laurent, A; Rose, Y Protein kinase inhibitors US Patent  US9822120 Publication Date 11/21/2017 
Target
Name:
Tyrosine-protein kinase BTK
Synonyms:
AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:
Enzyme
Mol. Mass.:
76289.95
Organism:
Homo sapiens (Human)
Description:
Q06187
Residue:
659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
  
Inhibitor
Name:
BDBM359860
Synonyms:
US9822120, Compound 14
Type:
Small organic molecule
Emp. Form.:
C28H26FN5O4S
Mol. Mass.:
547.601
SMILES:
Cc1ncc(COc2cc(F)cc(Oc3ccc(cc3)-c3nc(C4CC(O)(CO)C4)n4ccnc(N)c34)c2)s1 |(6.49,-1.11,;6.49,.43,;7.74,1.34,;7.26,2.8,;5.72,2.8,;4.63,3.89,;3.14,3.49,;2.05,4.58,;2.45,6.07,;1.36,7.16,;1.76,8.65,;-.12,6.76,;-.52,5.27,;-2.01,4.87,;-2.41,3.39,;-1.32,2.3,;-1.72,.81,;-3.21,.41,;-4.29,1.5,;-3.9,2.99,;-3.6,-1.08,;-2.7,-2.32,;-3.6,-3.57,;-3.21,-5.06,;-3.98,-6.39,;-2.64,-7.16,;-3.04,-8.65,;-1.1,-7.16,;-.33,-8.49,;-1.87,-5.83,;-5.07,-3.09,;-6.4,-3.86,;-7.74,-3.09,;-7.74,-1.55,;-6.4,-.78,;-6.4,.76,;-5.07,-1.55,;.57,4.18,;5.24,1.34,)|
Structure:
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