Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM359903
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<10±n/a nM
Citation
 Vechorkin, O; Li, Y Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors US Patent  US9822124 Publication Date 11/21/2017 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM359903
Synonyms:
N-(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyridin-3-yl)-3-(2,6-difluoro-3-methoxyphenyl)furo[3,2-b]pyridine-5-carboxamide | US9822124, Example 22
Type:
Small organic molecule
Emp. Form.:
C26H25F2N5O3
Mol. Mass.:
493.5052
SMILES:
COc1ccc(F)c(-c2coc3ccc(nc23)C(=O)Nc2cnccc2N2C[C@H](C)C[C@H](N)C2)c1F |r,wU:31.34,28.31,(1.29,6.62,;2.38,5.53,;1.98,4.05,;.48,3.59,;.08,2.11,;1.17,1.02,;.77,-.47,;2.66,1.42,;3.75,.33,;5.28,.49,;5.91,-.92,;4.76,-1.95,;4.76,-3.49,;3.43,-4.26,;2.1,-3.49,;2.1,-1.95,;3.43,-1.18,;.76,-4.26,;.76,-5.8,;-.57,-3.49,;-1.91,-4.26,;-1.91,-5.8,;-3.24,-6.57,;-4.57,-5.8,;-4.57,-4.26,;-3.24,-3.49,;-3.24,-1.95,;-1.91,-1.18,;-1.91,.36,;-.57,1.13,;-3.24,1.13,;-4.57,.36,;-5.91,1.13,;-4.57,-1.18,;3.06,2.9,;4.55,3.3,)|
Structure:
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