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Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM360340
Substrate
n/a
IC50
46.0±n/a nM
Citation
 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Oxazole orexin receptor antagonists US Patent  US9828368 Publication Date 11/28/2017 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
Hcrtr1 | Hypocretin receptor type 1 | OX1R_RAT | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Ox-1-R | Ox1-R | Ox1R
Type:
Protein
Mol. Mass.:
46817.55
Organism:
Rattus norvegicus (Rat)
Description:
P56718
Residue:
416
Sequence:
MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
  
Inhibitor
Name:
BDBM360340
Synonyms:
(2-(2H-1,2,3-Triazol-2-yl)phenyl)((2R,5R)-5-(4-(2- (hydroxymethyl)phenyl)oxazol-2-yl)-2- methylpiperidin-l-yl)methanone | US9828368, Example 5
Type:
Small organic molecule
Emp. Form.:
C26H27N5O2
Mol. Mass.:
441.5249
SMILES:
CCc1ccccc1-c1coc(n1)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1
Structure:
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