Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM360395
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
18.0±n/a nM
Citation
 Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Oxazole orexin receptor antagonists US Patent  US9828368 Publication Date 11/28/2017 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM360395
Synonyms:
(4-(2H-1,2,3-triazol-2-yl)thiophen-3- yl)((2R,5R)-5-(4-((R)-2-hydroxybutan-2- yl)-5-methyloxazol-2-yl)-2- methylpiperidin-1-yl)methanone | US9828368, Example 47
Type:
Small organic molecule
Emp. Form.:
C21H27N5O3S
Mol. Mass.:
429.536
SMILES:
CC[C@@](C)(O)c1nc(oc1C)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1cscc1-n1nccn1
Structure:
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