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Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM360557
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay
IC50
6111±n/a nM
Citation
 Imbriglio, J; London, C; Lu, Z; Tata, J; Xiong, Y; You, M; Youm, H Isoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 US Patent  US9828369 Publication Date 11/28/2017 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM360557
Synonyms:
N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2-methyl-2-((4- (trifluoromethyl)pyridin-2- yl)oxy)propanamide | US9828369, Example 114
Type:
Small organic molecule
Emp. Form.:
C27H24F3N3O3
Mol. Mass.:
495.493
SMILES:
COc1cccc(c1)-c1ccc(CNC(=O)C(C)(C)Oc2cc(ccn2)C(F)(F)F)c2cnccc12
Structure:
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