Reaction Details Report a problem with these data
Target
Cytosolic arginine sensor for mTORC1 subunit 1
Ligand
BDBM315574
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<5±n/a nM
Citation
 Ren, P; Liu, Y; Li, L; Chan, K; Wilson, TE Kinase inhibitors and methods of use US Patent  US9828378 Publication Date 11/28/2017 
Target
Name:
Cytosolic arginine sensor for mTORC1 subunit 1
Synonyms:
CAST1_HUMAN | CASTOR1 | Cellular arginine sensor for mTORC1 protein 1 | GATS-like protein 3 | GATSL3 | mTORC1 protein 1
Type:
Protein
Mol. Mass.:
36264.36
Organism:
Homo sapiens (Human)
Description:
Q8WTX7
Residue:
329
Sequence:
MELHILEHRVRVLSVARPGLWLYTHPLIKLLFLPRRSRCKFFSLTETPEDYTLMVDEEGFKELPPSEFLQVAEATWLVLNVSSHSGAAVQAAGVTKIARSVIAPLAEHHVSVLMLSTYQTDFILVREQDLSVVIHTLAQEFDIYREVGGEPVPVTRDDSSNGFPRTQHGPSPTVHPIQSPQNRFCVLTLDPETLPAIATTLIDVLFYSHSTPKEAASSSPEPSSITFFAFSLIEGYISIVMDAETQKKFPSDLLLTSSSGELWRMVRIGGQPLGFDECGIVAQIAGPLAAADISAYYISTFNFDHALVPEDGIGSVIEVLQRRQEGLAS
  
Inhibitor
Name:
BDBM315574
Synonyms:
US10172858, Table 2.70 | US9828378, # 70
Type:
Small organic molecule
Emp. Form.:
C20H20ClN7O2
Mol. Mass.:
425.871
SMILES:
CC(=O)N1CCC(CC1)n1nc(-c2cc3cc(O)cc(Cl)c3[nH]2)c2c(N)ncnc12
Structure:
Search PDB for entries with ligand similarity: