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TargetBIR2
LigandBDBM242581
Substrate/Competitorn/a
Meas. Tech.TR-FRET Assay for BIR2 and BIR3
pH7.5±n/a
Temperature298.15±n/a K
IC50 324±n/a nM
Commentsextracted
Citation Chen, SDonnell, AFKester, RFLe, KLou, YMichoud, CRemiszewski, SRupert, KCWeisel, M Tetrahydro-benzodiazepinones US Patent US10053431 Publication Date 8/21/2018
More Info.:Get all data from this article,  Assay Method
 
BIR2
Name:BIR2
Synonyms:n/a
Type:Enzyme Catalytic Domain
Mol. Mass.:14676.71
Organism:n/a
Description:n/a
Residue:125
Sequence:
MRHHHHHHRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPD
YAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNL
NIRSE
 
BDBM242581
NameBDBM242581
Synonyms:(2S)-N-[5-(1-adamantylmethyl)-1-[(2- methoxynaphthalen-1-yl)methyl]-2,4- dioxo-1,5-benzodiazepin-3-yl]-2- (methylamino)butanamide | US10053431, 113
TypeSmall organic molecule
Emp. Form.C37H44N4O4
Mol. Mass.608.7697
SMILESCC[C@H](NC)C(=O)NC1C(=O)N(Cc2c(OC)ccc3ccccc23)c2ccccc2N(CC23CC4CC(CC(C4)C2)C3)C1=O |r,TLB:32:33:36:40.39.38,42:33:40:36.37.38,THB:42:37:40:33.41.34,41:33:36:40.39.38,41:39:36:33.42.34|
Structure
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