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TargetBIR2
LigandBDBM242611
Substrate/Competitorn/a
Meas. Tech.TR-FRET Assay for BIR2 and BIR3
pH7.5±n/a
Temperature298.15±n/a K
IC50 4.99±n/a nM
Commentsextracted
Citation Chen, SDonnell, AFKester, RFLe, KLou, YMichoud, CRemiszewski, SRupert, KCWeisel, M Tetrahydro-benzodiazepinones US Patent US10053431 Publication Date 8/21/2018
More Info.:Get all data from this article,  Assay Method
 
BIR2
Name:BIR2
Synonyms:6x Histidine-tagged BIR2 domain | amino acids 124-240 of XIAP
Type:Enzyme Catalytic Domain
Mol. Mass.:14676.71
Organism:Homo sapiens (Human)
Description:n/a
Residue:125
Sequence:
MRHHHHHHRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPD
YAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNL
NIRSE
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BDBM242611
NameBDBM242611
Synonyms:(2S)-N-(1-((6-bromo-2- methoxynaphthalen-1-yl)methyl)-2,4- dioxo-5-phenyl-2,3,4,5-tetrahydro-1H- benzo[b][1,4]diazepin-3-yl)-2- (methylamino)propanamide | US10053431, 128
TypeSmall organic molecule
Emp. Form.C31H29BrN4O4
Mol. Mass.601.49
SMILESCN[C@@H](C)C(=O)NC1C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc2N(c2ccccc2)C1=O |r|
Structure
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n/a