Target
Gamma-aminobutyric acid type B receptor subunit 2
Ligand
BDBM360738
Substrate
n/a
Meas. Tech.
GTPgS Binding Assay
EC50
1540±n/a nM
Citation
 Faghih, RMoeller, AOchse, MPohlki, FSchmidt, MSippy, KTurner, SVan Der Kam, EL Substituted pyrazolopyrimidines and method of use US Patent  US9828381 Publication Date 11/28/2017 
Target
Name:
Gamma-aminobutyric acid type B receptor subunit 2
Synonyms:
GABA B receptor | GABR2_RAT | Gabbr2 | Gpr51
Type:
PROTEIN
Mol. Mass.:
105775.46
Organism:
Rattus norvegicus
Description:
O88871
Residue:
940
Sequence:
MASPPSSGQPRPPPPPPPPARLLLPLLLSLLLWLAPGAWGWTRGAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHFRWRRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAFEESMFGSKYQWIIPGWYEPAWWEQVHVEANSSRCLRRSLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQFEREYNSKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGKIILNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVERYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILSLGNFTESTDGGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILHHAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL
  
Inhibitor
Name:
BDBM360738
Synonyms:
US9828381, 9-1
Type:
Small organic molecule
Emp. Form.:
C20H24ClN5O
Mol. Mass.:
385.89
SMILES:
CC(c1cc2nc(C)cc(N3CCCC(CO)C3)n2n1)c1ccc(Cl)cn1
Structure:
Search PDB for entries with ligand similarity: