Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM360760
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<1000±n/a nM
Citation
 Wiles, JA; Pais, G; Hashimoto, A; Gadhachanda, VR; Wang, Q; Chen, D; Wang, X; Agarwal, A; Deshpande, M; Phadke, AS Alkyne compounds for treatment of complement mediated disorders US Patent  US9828396 Publication Date 11/28/2017 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM360760
Synonyms:
(2S,4R)-1-(2-(3-acetyl-5- (pyrimidin-2-ylethynyl)-1H- indol-1-yl)acetyl)-N-(3- chloro-2-fluorobenzyl)-4- fluoropyrrolidine-2- carboxamide | US9828396, Compound 9
Type:
Small organic molecule
Emp. Form.:
C30H24ClF2N5O3
Mol. Mass.:
575.993
SMILES:
CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2ccc(cc12)C#Cc1ncccn1 |r|
Structure:
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