Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM360837
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<1000±n/a nM
Citation
 Wiles, JA; Pais, G; Hashimoto, A; Gadhachanda, VR; Wang, Q; Chen, D; Wang, X; Agarwal, A; Deshpande, M; Phadke, AS Alkyne compounds for treatment of complement mediated disorders US Patent  US9828396 Publication Date 11/28/2017 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM360837
Synonyms:
1-(2-((2S,4R)-2-(6-(2- chloro-6- fluorophenyl)pyrazin-2- ylcarbamoyl)-4- fluoropyrrolidin-1-yl)-2- oxoethyl)-5-((5- fluoropyrimidin-2- yl)ethynyl)-1H-indazole-3- carboxamide | US9828396, Compound 86
Type:
Small organic molecule
Emp. Form.:
C31H21ClF3N9O3
Mol. Mass.:
660.005
SMILES:
NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cncc(n2)-c2c(F)cccc2Cl)c2ccc(cc12)C#Cc1ncc(F)cn1 |r|
Structure:
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