Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM19149
Substrate
BDBM19150
Meas. Tech.
HDAC Enzyme Activity Assay
pH
8±n/a
Temperature
310.15±n/a K
IC50
775±167 nM
Comments
MCF7 cells growth inhibition, IC50=500 nM.HeLa nuclear HDACs inhibition, IC50=288 +/- 59 nM
Citation
 Yurek-George, A; Cecil, AR; Mo, AH; Wen, S; Rogers, H; Habens, F; Maeda, S; Yoshida, M; Packham, G; Ganesan, A The First Biologically Active Synthetic Analogues of FK228, the Depsipeptide Histone Deacetylase Inhibitor. J Med Chem 50:5720-5726 (2007) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM19149
Synonyms:
CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA | US10011611, SAHA | US10188756, Compound SAHA | US11207431, SAHA | US11505523, Compound SAHA | US9115116, SAHA | US9353061, SAHA | US9428447, SAHA | US9695181, Vorinostat | Vorinostat | Zolinza | cid_5311 | suberoylanilide hydroxamic acid
Type:
Small organic molecule
Emp. Form.:
C14H20N2O3
Mol. Mass.:
264.3202
SMILES:
ONC(=O)CCCCCCC(=O)Nc1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM19150
Synonyms:
Ac-Arg-Gly-Lys(Ac)-AMC | Ac-KGLGK(Ac)-AMC
Type:
Fluorescent Peptide
Emp. Form.:
C28H40N8O7
Mol. Mass.:
600.6666
SMILES:
[#6]-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](-[#6])=O)-[#6](=O)-[#7]-c1ccc2c(-[#6])cc(=O)oc2c1
Structure:
Search PDB for entries with ligand similarity: