Reaction Details Report a problem with these data
Target
Histone deacetylase 6
Ligand
BDBM19156
Substrate
BDBM19150
Meas. Tech.
HDAC Enzyme Activity Assay
pH
8±n/a
Temperature
310.15±n/a K
IC50
>100000±n/a nM
Citation
 Bhuiyan, MP; Kato, T; Okauchi, T; Nishino, N; Maeda, S; Nishino, TG; Yoshida, M Chlamydocin analogs bearing carbonyl group as possible ligand toward zinc atom in histone deacetylases. Bioorg Med Chem 14:3438-46 (2006) [PubMed]  Article 
Target
Name:
Histone deacetylase 6
Synonyms:
HD6 | HDAC6_MOUSE | Hdac6 | Histone Deacetylase 6 (HDAC6) | Histone deacetylase | Histone deacetylase mHDA2
Type:
PROTEIN
Mol. Mass.:
125762.28
Organism:
Mus musculus
Description:
ChEMBL_1460074
Residue:
1149
Sequence:
MTSTGQDSSTRQRKSRHNPQSPLQESSATLKRGGKKCAVPHSSPNLAEVKKKGKMKKLSQPAEEDLVVGLQGLDLNPETRVPVGTGLVFDEQLNDFHCLWDDSFPESPERLHAIREQLILEGLLGRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLAETYDSVYLHPNSYSCACLATGSVLRLVDALMGAEIRNGMAVIRPPGHHAQHNLMDGYCMFNHLAVAARYAQKKHRIQRVLIVDWDVHHGQGTQFIFDQDPSVLYFSIHRYEHGRFWPHLKASNWSTIGFGQGQGYTINVPWNQTGMRDADYIAAFLHILLPVASEFQPQLVLVAAGFDALHGDPKGEMAATPAGFAHLTHLLMGLAGGKLILSLEGGYNLRALAKGVSASLHTLLGDPCPMLESCVVPCASAQTSIYCTLEALEPFWEVLERSVETQEEDEVEEAVLEEEEEEGGWEATALPMDTWPLLQNRTGLVYDEKMMSHCNLWDNHHPETPQRILRIMCHLEEVGLAARCLILPARPALDSELLTCHSAEYVEHLRTTEKMKTRDLHREGANFDSIYICPSTFACAKLATGAACRLVEAVLSGEVLNGIAVVRPPGHHAEPNAACGFCFFNSVAVAARHAQIIAGRALRILIVDWDVHHGNGTQHIFEDDPSVLYVSLHRYDRGTFFPMGDEGASSQVGRDAGIGFTVNVPWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLISAGFDAAQGDPLGGCQVTPEGYAHLTHLLMGLAGGRIILILEGGYNLASISESMAACTHSLLGDPPPQLTLLRPPQSGALVSISEVIQVHRKYWRSLRLMKMEDKEECSSSRLVIKKLPPTASPVSAKEMTTPKGKVPEESVRKTIAALPGKESTLGQAKSKMAKAVLAQGQSSEQAAKGTTLDLATSKETVGGATTDLWASAAAPENFPNQTTSVEALGETEPTPPASHTNKQTTGASPLQGVTAQQSLQLGVLSTLELSREAEEAHDSEEGLLGEAAGGQDMNSLMLTQGFGDFNTQDVFYAVTPLSWCPHLMAVCPIPAAGLDVSQPCKTCGTVQENWVCLTCYQVYCSRYVNAHMVCHHEASEHPLVLSCVDLSTWCYVCQAYVHHEDLQDVKNAAHQNKFGEDMPHSH
  
Inhibitor
Name:
BDBM19156
Synonyms:
(3S,9S,14aR)-9-benzyl-3-(hept-6-en-1-yl)-6,6-dimethyl-tetradecahydropyrrolo[1,2-a][,,,]cyclododecane-1,4,7,10-tetrone | cyclo(-L-Ae9-Aib-L-Phe-D-Pro-), 1
Type:
Small organic molecule
Emp. Form.:
C27H38N4O4
Mol. Mass.:
482.615
SMILES:
CC1(C)NC(=O)[C@H](CCCCCC=C)NC(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM19150
Synonyms:
Ac-Arg-Gly-Lys(Ac)-AMC | Ac-KGLGK(Ac)-AMC
Type:
Fluorescent Peptide
Emp. Form.:
C28H40N8O7
Mol. Mass.:
600.6666
SMILES:
[#6]-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](-[#6])=O)-[#6](=O)-[#7]-c1ccc2c(-[#6])cc(=O)oc2c1
Structure:
Search PDB for entries with ligand similarity: