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Targetmineralocorticoid
LigandBDBM19192
Substrate/CompetitorBDBM19214
IC50>5000±n/a nM
Citation Ali, AThompson, CFBalkovec, JMGraham, DWHammond, MLQuraishi, NTata, JREinstein, MGe, LHarris, GKelly, TMMazur, PPandit, SSantoro, JSitlani, AWang, CWilliamson, JMiller, DKThompson, CMZaller, DMForrest, MJCarballo-Jane, ELuell, S Novel N-arylpyrazolo[3,2-c]-based ligands for the glucocorticoid receptor: receptor binding and in vivo activity. J Med Chem47:2441-52 (2004) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
mineralocorticoid
Name:mineralocorticoid
Synonyms:MR | Mineralocorticoid Receptor (MR) | Mineralocorticoid receptor | Nuclear receptor subfamily 3 group C member 2
Type:Enzyme Catalytic Domain
Mol. Mass.:106748.15
Organism:RAT
Description:mineralocorticoid 0 RAT::P22199
Residue:981
Sequence:
METKGYHSLPEGLDMERRWSQVSQTLERSSLGPAERTTENNYMEIVNVSCVSGAIPNNST
QGSSKEKHELLPYIQQDNSRSGILPSDIKTELESKELSATVAESMGLYMDSVRDAEYTYD
QQNQQGSLSPTKIYQNMEQLVKFYKENGHRSSTLSAMSRPLRSFMPDSAASMNGGALRAI
VKSPIICHEKSSSVSSPLNMASSVCSPVGINSMSSSTTSFGSFPVHSPITQGTSLTCSPS
VENRGSRSHSPTHASNVGSPLSSPLSSMKSPISSPPSHCSVKSPVSSPNNVPLRSSVSSP
ANLNNSRCSVSSPSNNTNNRSTLSSPTASTVGSIGSPISNAFSYATSGASAGAGAIQDVV
PSPDTHEKGAHDVPFPKTEEVEKAISNGVTGPLNIVQYIKSEPDGAFSSSCLGGNSKISP
SSPFSVPIKQESSKHSCSGASFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPG
FDGSCEDSAFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSP
RDQSFQHLSSFPPVNTLVESWKPHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRP
SKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACR
LQKCLQAGMNLGARKSKKLGKLKGLHEEQPQQPPPPPPQSPEEGTTYIAPTKEPSVNSAL
VPQLTSITHALTPSPAMILENIEPETVYAGYDNSKPDTAESLLSTLNRLAAKQMIQVVKW
AKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQLLYFAPDLVFNEEKMHQS
AMYELCQGMRQISLQFVRLQLTFEEYSIMKVLLLLSTVPKDGLKSQAAFEEMRTNYIKEL
RKMVTKCPNSSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESQALKVEFPAMLVEI
ITDQLPKVESGNAKPLYFHRK
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  Blast E-value cutoff:
BDBM19192
NameBDBM19192
Synonyms:(R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl](4-fluorophenyl)methanol | BMCL173354 benzo[f]indazole, 6 | CHEMBL79807 | N-Arylpyrazolo[3,2-c]-Based Ligand, 11
TypeSmall organic molecule
Emp. Form.C25H24F2N2O
Mol. Mass.406.4677
SMILES[H][C@@]1(CCCC2=Cc3c(C[C@]12C)cnn3-c1ccc(F)cc1)[C@@H](O)c1ccc(F)cc1 |r,t:5|
Structure
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BDBM19214
NameBDBM19214
Synonyms:(1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-2-methyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-ene-15-carbaldehyde | Aldosterone | US10188667, Aldosterone | [3H]Aldosterone
TypeSteroid
Emp. Form.C21H28O5
Mol. Mass.360.444
SMILES[H][C@@]12CC[C@H](C(=O)CO)[C@]1(C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C)C=O |t:21|
Structure
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